Temozolomide

Chemodex

Temozolomide [85622-93-1]

10

85622-93-1

Research Use Only

>98%

Danger

C6H6N6O2

194.15

Chemical. CAS: 85622-93-1. Formula: C6H6N6O2. MW: 194.15. Temozolomide is a DNA methylating agent and drug resistance-modifying agent with antitumor and antiangiogenic properties. Temozolomide induces G2/M arrest and apoptosis through adduction of a methyl group to O6 position of guanine in genomic DNA and interfering with DNA replication and leading to cytotoxicity in proliferating cells. It has been shown to induce autophagy in malignant glioma cells. It is effective in a variety of types of cancer, including aggressive brain cancers. - Temozolomide is a DNA methylating agent and drug resistance-modifying agent with antitumor and antiangiogenic properties. Temozolomide induces G2/M arrest and apoptosis through adduction of a methyl group to O6 position of guanine in genomic DNA and interfering with DNA replication and leading to cytotoxicity in proliferating cells. It has been shown to induce autophagy in malignant glioma cells. It is effective in a variety of types of cancer, including aggressive brain cancers.

O=C1N(C)N=NC2=C(C(N)=O)N=CN21

2°C to 8°C,RT

12352200