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Temuterkib

HY-101494
MedChem Express
CAS Number1951483-29-6
DownloadMSDS
Product group Chemicals
Estimated Purity99.94
Molecular Weight453.56
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Overview

  • Supplier
    MedChem Express
  • Product Name
    Temuterkib [1951483-29-6]
  • Delivery Days Customer
    5
  • CAS Number
    1951483-29-6
  • Certification
    Research Use Only
  • Estimated Purity
    99.94
  • Molecular Formula
    C22H27N7O2S
  • Molecular Weight
    453.56
  • Scientific Description
    Temuterkib (LY3214996) is a highly selective inhibitor of ERK1 and ERK2 , with IC 50 of 5 nM for both enzymes in biochemical assays. Temuterkib potently inhibits cellular p-RSK1 in BRAF and RAS mutant cancer cell lines. Temuterkib shows potent antitumor activities in cancer models with MAPK pathway alterations.
  • SMILES
    O=C(C(C=C(C1=NC(NC2=CC=NN2C)=NC=C1)S3)=C3C4(C)C)N4CCN5CCOCC5
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200