Tetramethylrhodamine ethyl ester perchlorate [115532-52-0]

Chemodex

Tetramethylrhodamine ethyl ester perchlorate [115532-52-0]

2

115532-52-0

Research Use Only

>90%

Warning

C26H27N2O3 . ClO4

514.95

Chemical. CAS: 115532-52-0. Formula: C26H27N2O3 . ClO4. MW: 514.95. Tetramethylrhodamine ethyl ester perchlorate (TMRE) is a cell-permeant, cationic fluorescent dye widely used to assess mitochondrial membrane potential and for labeling mitochondria in live-cell imaging and flow cytometry. By selectively accumulating in active mitochondria according to their membrane potential, TMRE enables real-time monitoring of mitochondrial function, bioenergetics, and apoptosis-related depolarization events. Due to the polarization of the mitochondrial membrane, TMRE is taken up into healthy mitochondria, but when the membrane is depolarized, it is released from the mitochondria. Thus, the strength of the fluorescence signal in mitochondria is used to assess cell viability. TMRE is commonly applied in studies of neurobiology, cardiology, toxicology, and metabolic research to investigate mitochondrial dynamics, oxidative stress, and cellular responses to pharmacological agents. TMRE is slightly more hydrophobic than TMRM. Spectral Data: lambdaEx=555 nm; lambdaEx=574 nm (red-orange). - Tetramethylrhodamine ethyl ester perchlorate (TMRE) is a cell-permeant, cationic fluorescent dye widely used to assess mitochondrial membrane potential and for labeling mitochondria in live-cell imaging and flow cytometry. By selectively accumulating in active mitochondria according to their membrane potential, TMRE enables real-time monitoring of mitochondrial function, bioenergetics, and apoptosis-related depolarization events. Due to the polarization of the mitochondrial membrane, TMRE is taken up into healthy mitochondria, but when the membrane is depolarized, it is released from the mitochondria. Thus, the strength of the fluorescence signal in mitochondria is used to assess cell viability. TMRE is commonly applied in studies of neurobiology, cardiology, toxicology, and metabolic research to investigate mitochondrial dynamics, oxidative stress, and cellular responses to pharmacological agents. TMRE is slightly more hydrophobic than TMRM. Spectral Data: lambdaEx=555 nm; lambdaEx=574 nm (red-orange).

CN(C)C1=CC=C2C(OC(C3=C2C4=C(C(OCC)=O)C=CC=C4)=C/C(C=C3)=[N+](C)/C)=C1.O=Cl(=O)([O-])=O

2°C to 8°C,RT

12162000