TG 100801

MedChem Express

TG 100801 [867331-82-6]

10

867331-82-6

Research Use Only

98.61

C33H30ClN5O3

580.08

TG 100801 is a proagent that generates TG 100572 by de-esterification in development to treat age-related macular degeneration. TG 100572 is a multi-targeted kinase inhibitor which inhibits receptor tyrosine kinases and Src kinases ; has IC 50 s of 2, 7, 2, 16, 13, 5, 0.5, 6, 0.1, 0.4, 1, 0.2 for VEGFR1, VEGFR2, FGFR1, FGFR2, PDGFRbeta, Fgr, Fyn, Hck, Lck, Lyn, Src, Yes, respectively.

O=C(C1=CC=CC=C1)OC2=CC=C(Cl)C(C3=CC(C)=C(N=C(NC(C=C4)=CC=C4OCCN5CCCC5)N=N6)C6=C3)=C2

-20°C,2°C to 8°C

12352200