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Chemical Structure
Chemical Structure
Chemical Structure

TG003 [300801-52-9]

Research Use Only
AG-CR1-3656
AdipoGen Life Sciences
CAS Number300801-52-9
Product group Chemicals
Estimated Purity>98%
Molecular Weight249.3
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    TG003
  • Delivery Days Customer
    10
  • CAS Number
    300801-52-9
  • Certification
    Research Use Only
  • Estimated Purity
    >98%
  • Hazard Information
    Warning
  • Molecular Formula
    C13H15NO2S
  • Molecular Weight
    249.3
  • Scientific Description
    Chemical. CAS: 300801-52-9. Formula: C13H15NO2S. MW: 249.3. Synthetic. Potent, specific, reversible and ATP-competitive cell permeable inhibitor of Cdc2-like kinase (Clk) (IC50=15nM, 20nM, 200nM and >10microM for mClk4, mClk1, mClk2 and mClk3, respectively). Cdc2-like kinase (Clk), among a number of other kinases, phosphorylates serine/arginine-rich proteins which play a role in alternative splicing of pre-mRNA. DYRK1A and DYRK1B inhibitor. Splicing modulator compound. Regulates alternative splicing and reduces the phosphorylation of SF2/ASF1. Suppresses serine/arginine-rich protein phosphorylation and affects the regulation of alternative splicing by phosphorylation of SR protein both in vitro and in vivo. Potential drug for Duchenne muscular dystrophy. The reduction of Clk2 expression in the hypothalamus by chronic pharmacological inhibition abolished the anorexigenic effect of insulin and leptin, to increase body weight, fat mass, food intake and to decrease energy expenditure in mice. - Potent, specific, reversible and ATP-competitive cell permeable inhibitor of Cdc2-like kinase (Clk) (IC50=15nM, 20nM, 200nM and >10microM for mClk4, mClk1, mClk2 and mClk3, respectively). Cdc2-like kinase (Clk), among a number of other kinases, phosphorylates serine/arginine-rich proteins which play a role in alternative splicing of pre-mRNA. DYRK1A and DYRK1B inhibitor. Splicing modulator compound. Regulates alternative splicing and reduces the phosphorylation of SF2/ASF1. Suppresses serine/arginine-rich protein phosphorylation and affects the regulation of alternative splicing by phosphorylation of SR protein both in vitro and in vivo. Potential drug for Duchenne muscular dystrophy. The reduction of Clk2 expression in the hypothalamus by chronic pharmacological inhibition abolished the anorexigenic effect of insulin and leptin, to increase body weight, fat mass, food intake and to decrease energy expenditure in mice.
  • SMILES
    CC(/C=C1SC2=CC=C(OC)C=C2N\1CC)=O
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    51202000