TG101209 [936091-14-4] [936091-14-4]

Bioss

TG101209 [936091-14-4] [936091-14-4]

16

936091-14-4

Research Use Only

Unconjugated

98 - 98.0

C26 H35 N7 O2 S

509.67

TG101209 is a novel and potent JAK2 inhibitor, which induced dose- and time-dependent cytotoxicity in a variety of multiple myeloma (MM) cell lines. The induction of cytotoxicity was associated with inhibition of cell cycle progression and induction of apoptosis in myeloma cell lines and patient-derived plasma cells. Exploring the mechanism of action of TG101209 indicated downregulation of pJak2, pStat3, and Bcl-xl levels with upregulation of pErk and pAkt levels indicating cross talk between signaling pathways. TG101209 , when used in combination with the PI3K inhibitor LY294002, demonstrated synergistic cytotoxicity against myeloma cells.

CN1CCN(CC1)C1C=CC(=CC=1)NC1N=C(NC2C=C(C=CC=2)S(=O)(=O)NC(C)(C)C)C(C)=CN=1

-20°C

12161509