TG101209 [936091-14-4]

MedChem Express

TG101209 [936091-14-4]

10

936091-14-4

Research Use Only

99.22

C26H35N7O2S

509.67

TG101209 is a selective JAK2 inhibitor with IC50 of 6 nM, less potent to Flt3 and RET with IC50 of 25 nM and 17 nM, appr 30-fold selective for JAK2 than JAK3, and sensitive to JAK2V617F and MPLW515L/K mutations.

O=S(C1=CC=CC(NC2=NC(NC3=CC=C(C=C3)N4CCN(CC4)C)=NC=C2C)=C1)(NC(C)(C)C)=O

-20°C,2°C to 8°C

12352200