TGF-beta(1D11.16.8), CF740 conjugate, 0.1mg/mL

Biotium

TGF-beta(1D11.16.8), CF740 conjugate, 0.1mg/mL

16

Functional Assay, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Monoclonal

1D11.16.8

0.1 mg/ml

Other Conjugate

TGFB1

transforming growth factor beta 1

CED, DPD1, IBDIMDE, LAP, TGF-beta1, TGFB, TGFbeta, transforming growth factor beta-1 proprotein, TGF-beta-1, latency-associated peptide, prepro-transforming growth factor beta-1, transforming growth factor beta1

IgG1

Transforming growth factor beta-1 proprotein

This MAb recognizes TGF beta 1, 2 and 3. Three TGF-betas have been identified in mammals. TGF-beta1, TGF-beta2 and TGF-beta3 are each synthesized as precursor proteins that are very similar in that each is cleaved to yield a 112 amino acid polypeptide that remains associated with the latent portion of the molecules. Biologically active TGF-beta requires dimerization of the monomers (usually homodimers) and release of the latent peptide portion. Overall, the mature region of the TGF-beta3 protein has approximately 80% identity to the mature region of both TGF-beta1 and TGF-beta2. However, the NH2 terminals or precursor regions of their molecules share only 27% sequence identity. TGF-betas inhibit the growth of epithelial cells and stimulate the growth of mesenchymal cells.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Animal

2°C to 8°C,RT

41116100