TGN46 antibody
GTX74290
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen
Product group Antibodies
TargetTGOLN2
Overview
- SupplierGeneTex
- Product NameTGN46 antibody
- Delivery Days Customer9
- Application Supplier NoteWB: 1/500-1/1,000. IHC-Fr: 1/50-1/100. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- Gene ID10618
- Target nameTGOLN2
- Target descriptiontrans-golgi network protein 2
- Target synonymsTGN38, TGN46, TGN48, TGN51, TTGN2, hTGN46, hTGN48, hTGN51, trans-Golgi network integral membrane protein 2, TGN38 homolog, trans-Golgi network glycoprotein 46, trans-Golgi network glycoprotein 48, trans-Golgi network glycoprotein 51, trans-Golgi network protein TGN51
- HostSheep
- IsotypeIgG
- Protein IDO43493
- Protein NameTrans-Golgi network integral membrane protein 2
- Scientific DescriptionThis gene encodes a type I integral membrane protein that is localized to the trans-Golgi network, a major sorting station for secretory and membrane proteins. The encoded protein cycles between early endosomes and the trans-Golgi network, and may play a role in exocytic vesicle formation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Harder NHO, Lee HP, Flood VJ, et al. Fatty Acid Uptake in Liver Hepatocytes Induces Relocalization and Sequestration of Intracellular Copper. Front Mol Biosci. 2022,9:863296. doi: 10.3389/fmolb.2022.863296Read this paper
- McCann CJ, Jayakanthan S, Siotto M, et al. Single nucleotide polymorphisms in the human ATP7B gene modify the properties of the ATP7B protein. Metallomics. 2019,11(6):1128-1139. doi: 10.1039/c9mt00057gRead this paper
- McGough IJ, de Groot REA, Jellett AP, et al. SNX3-retromer requires an evolutionary conserved MON2:DOPEY2:ATP9A complex to mediate Wntless sorting and Wnt secretion. Nat Commun. 2018,9(1):3737. doi: 10.1038/s41467-018-06114-3Read this paper
- Danson CM, Pearson N, Heesom KJ, et al. Sorting nexin-21 is a scaffold for the endosomal recruitment of huntingtin. J Cell Sci. 2018,131(17). doi: 10.1242/jcs.211672Read this paper
- Kane MS, Davids M, Bond MR, et al. Abnormal glycosylation in Joubert syndrome type 10. Cilia. 2017,6:2. doi: 10.1186/s13630-017-0048-6Read this paper
- Hatori Y, Yan Y, Schmidt K, et al. Neuronal differentiation is associated with a redox-regulated increase of copper flow to the secretory pathway. Nat Commun. 2016,7:10640. doi: 10.1038/ncomms10640Read this paper
- Davids M, Kane MS, He M, et al. Disruption of Golgi morphology and altered protein glycosylation in PLA2G6-associated neurodegeneration. J Med Genet. 2016,53(3):180-9. doi: 10.1136/jmedgenet-2015-103338Read this paper
- Malinouski M, Hasan NM, Zhang Y, et al. Genome-wide RNAi ionomics screen reveals new genes and regulation of human trace element metabolism. Nat Commun. 2014,5:3301. doi: 10.1038/ncomms4301Read this paper
- Huster D, Kühne A, Bhattacharjee A, et al. Diverse functional properties of Wilson disease ATP7B variants. Gastroenterology. 2012,142(4):947-956.e5. doi: 10.1053/j.gastro.2011.12.048Read this paper
- Dmitriev OY, Bhattacharjee A, Nokhrin S, et al. Difference in stability of the N-domain underlies distinct intracellular properties of the E1064A and H1069Q mutants of copper-transporting ATPase ATP7B. J Biol Chem. 2011,286(18):16355-62. doi: 10.1074/jbc.M110.198101Read this paper
Datasheet
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