TGX-115 is a cell-permeable and potent inhibitor of the PI 3-K isoform p110beta/p110delta (IC50 values of 0.13 microM for p110beta and 0.63 microM for p110delta), an enzyme that regulates platelet adhesion and inhibits phosphoinositide (PI) 3-kinase, and can be used to treat coronary artery occlusion, stroke, acute coronary artery It can be used to treat cardiovascular diseases such as coronary occlusion, stroke, acute coronary syndrome, acute myocardial infarction, restenosis, atherosclerosis and unstable angina.
