TH5487

MedChem Express

TH5487 [2304947-71-3]

10

2304947-71-3

Research Use Only

98.76

C19H18BrIN4O2

541.18

TH5487 is a potent 8-oxoguanine DNA glycosylase 1 ( OGG1 ) inhibitor with an IC 50 of 342 nM. TH5487 stops OGG1 from recognizing its DNA substrate, inhibits DNA repair and modifies OGG1 chromatin dynamics, which results in the inhibition of proinflammatory pathway genes [1] .

O=C(N1CCC(N(C2=CC=CC(Br)=C2N3)C3=O)CC1)NC4=CC=C(I)C=C4

-20°C,2°C to 8°C

12352200