Thailanstatin A

Biorbyt

Thailanstatin A [1426953-21-0]

10

1426953-21-0

Research Use Only

C28H41NO9

535.62644

Thailanstatin A is an ultra-potent inhibitor of eukaryotic RNA splicing (IC50=650 nM). Thailanstatin A exerts effects via non-covalent binding to the SF3b subunit of the U2 snRNA subcomplex of the spliceosome and shows low-nM to sub-nM IC50s against multiple cancer cell lines. Thailanstatin A, a payload for ADCs, is conjugated to the lysines on trastuzumab yielding linker-less ADC.

CC(=O)OC(C)\C=C\C(=O)NC1C(C)OC(C\C=C(/C)\C=C\C2C(O)C3(CC(CC(O)=O)O2)OC3)C(C)C1

12352200