Thalidomide 5-fluoride

MedChem Express

Thalidomide 5-fluoride [835616-61-0]

9

835616-61-0

Research Use Only

99.9

C13H9FN2O4

276.223

Thalidomide 5-fluoride is a thalidomide-based Cereblon ligand used to recruit Cereblon protein. Thalidomide 5-fluoride can be linked to target protein ligands (e.g. IRAK4) through a linker to form PROTAC molecules (e.g. PROTAC IRAK4 degrader-1). PROTAC IRAK4 degrader-1 caused 20-50%, and >50% IRAK4 protein degradation in OCI-LY-10 cells at concentrations of 0.01, 0.1, and 1 microM, respectively[1][2].

O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC(F)=C3)=O

-20°C,2°C to 8°C

12352200