Thalidomide-5-NH-CH2-COO(t-Bu)
HY-W584516
Product group Molecular Biology
Overview
- SupplierMedChem Express
- Product NameThalidomide-5-NH-CH2-COO(t-Bu)
- Delivery Days Customer14
- CertificationResearch Use Only
- Molecular FormulaC19H21N3O6
- Molecular Weight387.39
- Scientific DescriptionThalidomide-5-NH-CH2-COO(t-Bu) is a t-Bu modified Thalidomide (HY-14658), which acts as a Cereblon ligand to recruit CRBN protein. The t-Bu protecting group at the end of Thalidomide-5-NH-CH2-COO(t-Bu) can be removed under acidic conditions to participate in the synthesis of PROTAC molecules. Thalidomide-5-NH-CH2-COO(t-Bu) is a key intermediate in the synthesis of CRBN-based PROTAC molecules.
- SMILESO=C(OC(C)(C)C)CNC1=CC2=C(C(N(C(CC3)C(NC3=O)=O)C2=O)=O)C=C1
- UNSPSC41115800