Thalidomide-5-(PEG2-amine)

MedChem Express

Thalidomide-5-(PEG2-amine)

5

Research Use Only

C20H24N4O7

432.43

Thalidomide-5-(PEG2-amine) is a PROTAC building block that contains an E3 ligase ligand substituted with a terminal amine group. The amine group can react with NHS ester group or carboxylic acid in the presence of EDC or HATU. The PEG spacer improves water solubility.

NCCOCCOCCNC(C1=CC=C2C(N(C(C2=C1)=O)C3CCC(NC3=O)=O)=O)=O

41115800