Thalidomide-propargyl [2098487-39-7]

MedChem Express

Thalidomide-propargyl [2098487-39-7]

10

2098487-39-7

Research Use Only

99.97

C16H12N2O5

312.281

Thalidomide-propargyl is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide-propargyl can be connected to the ligand for protein by a linker to form the IMiD containing PROTACs[1]. Thalidomide-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3OCC#C)=O

-20°C,2°C to 8°C

41116133