Theliatinib (tartrate) [2413487-72-4]
HY-104066A
CAS Number2413487-72-4
Product group Chemicals
Molecular Weight592.60
Overview
- SupplierMedChem Express
- Product NameTheliatinib (tartrate) [2413487-72-4]
- Delivery Days Customer10
- CAS Number2413487-72-4
- CertificationResearch Use Only
- Molecular FormulaC29H32N6O8
- Molecular Weight592.60
- Scientific DescriptionTheliatinib (Xiliertinib) tartrate is a potent, ATP-competitive, orally active and highly selective EGFR inhibitor with a Ki of 0.05 nM and an IC50 of 3 nM. Theliatinib has an IC50 of 22 nM for EGFR T790M/L858R mutant. Theliatinib shows >50-fold selectivity for EGFR than other kinases[1]. Theliatinib (tartrate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- SMILESO=C(N1C[C@]2([H])N(C)CC[C@]2([H])C1)NC3=CC4=C(NC5=CC=CC(C#C)=C5)N=CN=C4C=C3OC.OC([C@H](O)[C@@H](O)C(O)=O)=O
- UNSPSC12352200