Thimet Oligopeptidase/THOP1 Protein, Mouse, Recombinant (His)
TMPY-02393
Product group Molecular Biology
Overview
- SupplierTargetMol Chemicals
- Product NameThimet Oligopeptidase/THOP1 Protein, Mouse, Recombinant (His)
- Delivery Days Customer16
- CertificationResearch Use Only
- Scientific DescriptionTHOP1, also known as Thimet oligopeptidase 1, Thimet oligopeptidase, EC 3.4.24.15, or EP24.15, is a zinc(II) endopeptidase implicated in the processing of numerous physiological peptides. As an intracellular enzyme, highly expressed in the brain, kidneys and neuroendocrine tissue, THOP1 has been proposed to metabolize peptides within cells, thereby affecting antigen presentation and G protein-coupled receptor signal transduction. Its substrates is gonadotrophin-releasing hormone (GnRH), an important hypothalamic hormone that regulates the synthesis and release of oestradiol and facilitates female sexual behaviour. THOP1 against toxic effects of Abeta in the early stages of Alzheimer disease (AD) pathology, and suggest that the observed increase in THOP1 expression might be part of a compensatory defense mechanism of the brain against an increased Abeta load.
- Storage Instruction-20°C
- UNSPSC12352204