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Thiocolchicine

HY-116852
MedChem Express
CAS Number2730-71-4
Product group Chemicals
Estimated Purity99.77
Molecular Weight415.50
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Overview

  • Supplier
    MedChem Express
  • Product Name
    Thiocolchicine [2730-71-4]
  • Delivery Days Customer
    10
  • CAS Number
    2730-71-4
  • Certification
    Research Use Only
  • Estimated Purity
    99.77
  • Molecular Formula
    C22H25NO5S
  • Molecular Weight
    415.50
  • Scientific Description
    Thiocolchicine, a derivative modified in the C Ring of Colchicine (HY-16569) with enhanced biological properties. Thiocolchicine is a potent inhibitor of tubulin polymerization ( IC 50 =2.5 microM) and competitively binds to tubulin with a K i of 0.7 microM. Thiocolchicine induces cell apoptosis [1] [2] . Thiocolchicine can be used as an ADC cytotoxin in ADC technology.
  • SMILES
    CC(N[C@H](C1=C2)CCC3=CC(OC)=C(OC)C(OC)=C3C1=CC=C(SC)C2=O)=O
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200

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