Thiocolchicine-d3

MedChem Express

Thiocolchicine-d3

10

Research Use Only

99.0

C22H22D3NO5S

418.52

Thiocolchicine-d3 is deuterium labeled Thiocolchicine. Thiocolchicine, a derivative modified in the C Ring of Colchicine (HY-16569) with enhanced biological properties. Thiocolchicine is a potent inhibitor of tubulin polymerization (IC50=2.5 microM) and competitively binds to tubulin with a Ki of 0.7 microM. Thiocolchicine induces cell apoptosis[1][2]. Thiocolchicine can be used as an ADC cytotoxin in ADC technology.

O=C(N[C@H](C1=C2)CCC3=CC(OC)=C(OC)C(OC)=C3C1=CC=C(SC)C2=O)C([2H])([2H])[2H]

2°C to 8°C

12352200