Thiolutin

MedChem Express

Thiolutin [87-11-6]

10

87-11-6

Research Use Only

99.16

C8H8N2O2S2

228.29

Thiolutin (Acetopyrrothin) is a disulfide-containing antibiotic and anti-angiogenic compound produced by Streptomyces . Thiolutin inhibits the JAMM metalloproteases Csn5, Associated-molecule-with-the-SH3-Domain-of-STAM (AMSH) and Brcc36 [1] . Thiolutin is a potent and selective inhibitor of endothelial cell adhesion accompanied by rapid induction of Heat-shock protein beta-1 (Hsp27) phosphorylation [2] .

CC(NC1=C2C(N(C)C1=O)=CSS2)=O

-20°C,2°C to 8°C

12352200