ThPok antibody

GeneTex

ThPok Antibody

9

WB: 1:500-1:3000. IHC-P: 1.25-2.5 microg/mL. ELISA: 1:2500-1:10000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Western Blot, ELISA, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Polyclonal

85 mg/ml

Unconjugated

Zbtb7b

zinc finger and BTB domain containing 7B

c-Kr; c-Krox; krueppel-related zinc finger protein cKrox; T-helper-inducing POZ/Krueppel-like factor; Thp; Thpok; Vzinc finger and BTB domain containing 7B; Zfp6; Zfp67; zinc finger and BTB domain-containing protein 7B; zinc finger protein 67; zinc finger protein Th-POK

Rabbit

IgG

Zinc finger and BTB domain-containing protein 7B

cKrox (also known as Zfp67 or ThPOK) functions as a transcription regulator that acts as a key modulator of lineage commitment for immature T-cell precursors. cKrox is necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. cKrox is a known transcriptional repressor of the collagen COL1A1 and COL1A2 genes and may also function as a repressor of fibronectin and possibly other extracellular matrix genes. cKrox is located within the nucleus and is expressed in multiple tissues and organs including skin, thymus and peripheral T-cells.

Human, Mouse, Rat

-20°C or -80°C,2°C to 8°C

12352203