THPP-1

MedChem Express

THPP-1 [1257051-63-0]

10

1257051-63-0

Research Use Only

98.75

C23H21ClN6O3

464.90

THPP-1, a SGC chemical probe, is a potent and orally bioavailable phosphodiesterase 10A (PDE10A) inhibitor, with K i values of 1 nM and 1.3 nM for human and rat PDE10A, respectively. THPP-1 has excellent pharmacokinetic properties in preclinical species [1] .

O=C(C1=C2C=CC=CN2C=N1)N3CCC4=NC(C5=CC=C(N=C5)Cl)=NC(OCCOC)=C4C3

-20°C,2°C to 8°C

12352200