THPTA, Tris((1-hydroxy-propyl-1H-1,2,3-triazol-4-yl)methyl)amine [760952-88-3]

Jena Bioscience

THPTA, Tris((1-hydroxy-propyl-1H-1,2,3-triazol-4-yl)methyl)amine [760952-88-3]

5

760952-88-3

Research Use Only

>95%

C18H30N10O3

434.50 g/mol

THPTA is a water-soluble, very effective ligand for Cu(I)-catalyzed Alkyne-Azide click chemistry reactions (CuAAC). It serves a dual purpose: 1) Accelaration of the CuAAC reaction by maintaining the Cu(I) oxidation state of copper sources and 2) Protection of biomolecules from oxidative damage during the labeling reaction[1,2]. THPTA is a superior alternative to water-insoluble TBTA. A stock solution can be prepared in ddH2O and subsequently be stored at -20°C. Avoid freeze-thaw cycles. Presolski et al.[1] and Hong et al.[2] provide a general protocol for CuAAC reactions that may be used as a starting point for the set up and optimization of individual assays.

N(Cc1nnn(c1)CCCO)(Cc1nnn(c1)CCCO)Cc1cn(nn1)CCCO

2°C to 8°C

12352200