THR-beta agonist 6 [2791290-58-7]

MedChem Express

THR-beta agonist 6 [2791290-58-7]

10

2791290-58-7

Research Use Only

C20H14Cl2N6O3

457.27

THR-beta agonist 6 is an orally active, selective thyroid hormone receptor beta (THR-beta) agonist with EC50s of 0.03 microM and 0.22 microM for THR-beta and THR-alpha, respectively. THR-beta agonist 6 exhibits an xcellent liver-to-serum ratio of 93:1 in mice. THR-beta agonist 6 has the potential for nonalcoholic steatohepatitis (NASH) research[1].

CC(C)N1C(C=CC2=C1C=CN2C3=C(Cl)C=C(N4N=C(C#N)C(NC4=O)=O)C=C3Cl)=O

12131703