Thrombin Receptor Peptide Ligand (trifluoroacetate salt)

TargetMol Chemicals

Thrombin Receptor Peptide Ligand (trifluoroacetate salt)

9

Chemical

Research Use Only

Thrombin Receptor Peptide Ligand (trifluoroacetate salt)

Thrombin receptor peptide ligand is antagonist of the thrombin receptor (EC50s = 16-33 microM to inhibit platelet aggregation in vitro). It inhibits alpha-thrombin and platelet aggregation induced by thrombin receptor activating peptide in vitro when used at a concentration of 32 microM but does not affect platelet aggregation induced by ADP or collagen. It also inhibits thrombin- and TRAP-induced proliferation of vascular smooth muscle cells (VSMCs). Thrombin receptor peptide ligand (100 micromol/kg bolus, i.v., plus 900 micromol/kg infusion) inhibits arterial thrombosis in a rabbit model of partial carotid artery occlusion without increasing bleeding time.

3 years

-20°C

12352202