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ProductsBack/Thyroglobulin antibody [2H11 + 6E1]

Thyroglobulin antibody [2H11 + 6E1]

Research Use Only
GTX01838
GeneTex
ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
DownloadDatasheet
Product group Antibodies
ReactivityHuman, Rat
TargetTG
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Overview

  • Supplier
    GeneTex
  • Product Name
    Thyroglobulin antibody [2H11 + 6E1]
  • Delivery Days Customer
    9
  • Antibody Specificity
    Clone [2H11 + 6E1] cocktail is especially designed for sensitive detection of thyroglobulin. It stains thyroglobulin in follicular epithelial cells as well as colloid tissue.
  • Application Supplier Note
    IHC-P: 1:100-1:200. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Clone ID
    2H11 + 6E1
  • Conjugate
    Unconjugated
  • Formulation
    Liquid
  • Gene ID7038
  • Target name
    TG
  • Target description
    thyroglobulin
  • Target synonyms
    AITD3; TGN; thyroglobulin
  • Host
    Mouse
  • Isotype
    IgG1
  • Protein IDP01266
  • Protein Name
    Thyroglobulin
  • Scientific Description
    Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis. [provided by RefSeq, Nov 2009]
  • Reactivity
    Human, Rat
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352203

References

  • Malignant teratoid tumor of the thyroid gland: an aggressive primitive multiphenotypic malignancy showing organotypical elements and frequent DICER1 alterations-is the term thyroblastoma more appropriate? Agaimy A et al., 2020 Dec, Virchows Arch
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  • Cytological diagnosis of a rare synchronous non-small cell lung cancer metastatic to the thyroid gland. Bizzarro T et al., 2020 Jul, Cytopathology
    Read more
  • Dissecting Anaplastic Thyroid Carcinoma: A Comprehensive Clinical, Histologic, Immunophenotypic, and Molecular Study of 360 Cases. Xu B et al., 2020 Oct, Thyroid
    Read more
  • Histopathology and immunohistochemistry as prognostic factors for poorly differentiated thyroid cancer in a series of Polish patients. Walczyk A et al., 2020, PLoS One
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  • Morphological and functional changes in neonatally X-irradiated thyroid gland in rats. Fujimoto N et al., 2020 Feb 28, Endocr J
    Read more