THZ1

MedChem Express

THZ1 [1604810-83-4]

10

1604810-83-4

Research Use Only

99.84

C31H28ClN7O2

566.05

THZ1 is a selective and potent covalent CDK7 inhibitor with an IC50 of 3.2 nM. THZ1 also inhibits the closely related kinases CDK12 and CDK13 and downregulates MYC expression[1][2].

ClC1=CN=C(NC2=CC(NC(C3=CC=C(NC(/C=C/CN(C)C)=O)C=C3)=O)=CC=C2)N=C1C4=CNC5=CC=CC=C54

-20°C,2°C to 8°C

12352200