THZ2

AbMole BioScience

THZ2

9

1604810-84-5

Chemical

Research Use Only

C31H28ClN7O2

566.05

THZ2 (an analog of THZ1) is a potent and selective CDK7 inhibitor which overcomes the instability of THZ1 in vivo (IC50s: CDK7=13.9 nM; TNBC cells=10 nM).

CN(C)C\C=C\C(=O)NC1=CC=CC(=C1)C(=O)NC2=CC=CC(=C2)NC3=NC=C(Cl)C(=N3)C4=C[NH]C5=CC=CC=C45

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