Timegadine [71079-19-1]

MedChem Express

Timegadine [71079-19-1]

10

71079-19-1

Research Use Only

C20H23N5S

365.50

Timegadine, a new antiinflammatory agent, is found to be a potent, competitive inhibitor of cyclo-oxygenase (COX) and lipo-oxygenase, with IC50s ranging from 5 nM (washed rabbit platelets) to 20 microM (rat brain) for COX and 100 microM for lipo-oxygenase both in the cytosol fraction of horse platelet homogenates, and in washed rabbit platelets.

CC1=NC2=CC=CC=C2C(/N=C(NC3CCCCC3)/NC4=NC=CS4)=C1

12352200