TIRAP blocking peptide

GeneTex

TIRAP blocking peptide

9

Research Use Only

TIRAP

TIR domain containing adaptor protein

BACTS1, Mal, MyD88-2, wyatt, toll/interleukin-1 receptor domain-containing adapter protein, MyD88 adapter-like protein, Toll-like receptor adaptor protein, adapter protein wyatt, adaptor protein Wyatt, toll-interleukin 1 receptor (TIR) domain containing adaptor protein

The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]

-20°C or -80°C,2°C to 8°C

41116100

Human