TIY-7

MedChem Express

TIY-7 [2846435-83-2]

10

Research Use Only

C21H18F4N6O

446.40

TIY-7 is a selective and orally active tropomyosin receptor kinase (TRK) inhibitor. TIY-7 shows enzyme inhibitory activity with IC50s of 2.9, 1.1, 0.7, 0.8, 0.8, 0.2 nM for TRKA, TRKAG595R, TRKAG667C, TRKAF589L, TRKCG623R, TRKCG696A, respectively. TIY-7 shows anti-tumor potency in mouse xenograft model[1].

FC1=CC=C(C([C@H]2CCCN2C3=NC4=C(C=NN4C=C3)C5=CNN=C5)=C1)OCC(F)(F)F

12131703