TK-684

MedChem Express

TK-684

999

Research Use Only

C17H21ClN8OS

420.92

TK-684 is a potent and selective allosteric SHP2 inhibitor with IC50 values of 2.1, >1000 nM for SHP2WT, SHP22PTP, respectively. TK-684 inhibits cell proliferation and induces apoptosis. TK-684 decreases the protein expression of p-AKT, p-ERK[1].

ClC1=C(N=CC=C1SC2=NNC(N=C(N3)N4CCC(C)(CC4)CN)=C2C3=O)N

12352200