TL02-59 (dihydrochloride)

MedChem Express

TL02-59 (dihydrochloride) [2415263-06-6]

10

2415263-06-6

Research Use Only

C32H36Cl2F3N5O4

682.56

TL02-59 dihydrochloride is an orally active, selective Src-family kinase Fgr inhibitor with an IC 50 of 0.03 nM. TL02-59 dihydrochloride inhibits Lyn and Hck with IC 50 s of 0.1 nM and 160 nM, respectively. TL02-59 dihydrochloride potently suppresses acute myelogenous leukemia (AML) cell growth [1] .

O=C(NC1=CC=C(CN2CCN(CC)CC2)C(C(F)(F)F)=C1)C3=CC=C(C)C(OC4=C5C=C(OC)C(OC)=CC5=NC=N4)=C3.Cl.Cl

12352200