TMEM16C antibody, C-term

GeneTex

TMEM16C antibody, C-term

9

WB: 0.2-2.5 ug/ml. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Western Blot

Research Use Only

Polyclonal

0.5-1 mg/ml

Unconjugated

ANO3

anoctamin 3

C11orf25, DYT23, DYT24, GENX-3947, TMEM16C, anoctamin-3, dystonia 23, transmembrane protein 16C (eight membrane-spanning domains)

Rabbit

IgG

Anoctamin-3

The protein encoded by this gene belongs to the TMEM16 family of predicted membrane proteins, that are also known as anoctamins. While little is known about the function of this gene, mutations in this gene have been associated with some cases of autosomal dominant craniocervical dystonia. Cells from individuals with a mutation in this gene exhibited abnormalities in endoplasmic reticulum-dependent calcium signaling. Studies in rat show that the rat ortholog of this protein interacts with, and modulates the activity of a sodium-activated potassium channel. Deletion of this gene caused increased pain sensitivity in the rat model system. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]

-20°C or -80°C,2°C to 8°C

12352203