TmpA partial (23-41aa and 288-325aa), Treponema Pallidum Membrane Protein A, Treponema pallidum, recombinant, E. coli

Jena Bioscience

TmpA partial (23-41aa and 288-325aa), Treponema Pallidum Membrane Protein A, Treponema pallidum, recombinant, E. coli

5

Research Use Only

>90%

The E. coli derived 68kDa recombinant protein contains the Trp. Pallidum TmpA immunodominant regions, 23-41 amino acids and 288-325 amino acids. Treponema pallidum is a gram-negative spirochaete bacterium and is considered to be metabolically crippled. There are at least four known subspecies: T. pallidum pallidum, T. pallidum pertenue, T. pallidum carateum and T. pallidum endemicum. The helical structure of T. pallidum pallidum allows it to move in a corkscrew motion through viscous mediums such as mucus. Treponema pallidum sub sp. pallidum has one of the smallest bacterial genomes at 1.14 million base pairs (Mb) and has limited metabolic capabilities, reflecting its adaptation through genome reduction to the rich environment of mammalian tissue. Background: Syphilis is a chronic, complex sexually transmitted disease of humans caused by the spirochetal bacterium Treponema pallidum. Humans are the only known reservoir for T. pallidum. One of the major immunoreactive proteins of T. pallidum is the lipoprotein TmpA. This protein migrates as a 44-kDa protein in SDS-PAGE gels. In vivo it is produced as a 46-kDa precursor which is cleaved during maturation and addition of lipid.

-20°C

12352202