TMPRSS2 Recombinant Protein

Aviva Systems Biology

TMPRSS2 Recombinant Protein

23

Western Blot, Other Application

Research Use Only

200 ug/ml

Unconjugated

>97%

Lyophilized 20mM Tris, 150mM NaCl, pH 8.0, containing 0.01% SKL, 5% Trehalose

TMPRSS2

transmembrane serine protease 2

PRSS10, transmembrane protease serine 2, epitheliasin, serine protease 10, transmembrane protease, serine 2

Serine protease that proteolytically cleaves and activates the viral spike glycoproteins which facilitate virus-cell membrane fusions; spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence. Facilitates human SARS coronavirus (SARS-CoV) infection via two independent mechanisms, proteolytic cleavage of ACE2, which might promote viral uptake, and cleavage of coronavirus spike glycoprotein which activates the glycoprotein for cathepsin L-independent host cell entry. Proteolytically cleaves and activates the spike glycoproteins of human coronavirus 229E (HCoV-229E) and human coronavirus EMC (HCoV-EMC) and the fusion glycoproteins F0 of Sendai virus (SeV), human metapneumovirus (HMPV), human parainfluenza 1, 2, 3, 4a and 4b viruses (HPIV). Essential for spread and pathogenesis of influenza A virus (strains H1N1, H3N2 and H7N9); involved in proteolytic cleavage and activation of hemagglutinin (HA) protein which is essential for viral infectivity.

E.coli

-80°C,2°C to 8°C

41116100

Human