TNF-alpha Antagonist [199999-60-5]

TargetMol Chemicals

TNF-alfa Antagonist

44

199999-60-5

Chemical

Research Use Only

TNF-alfa Antagonist

C58H71N11O15S2

1226.39

TNF-alpha antagonist is an exocyclic peptide that mimics the critical TNF-alpha recognition loop on TNF receptor I complex and, thus, prevents ligand interaction with the receptor. By blocking the TNF receptor ligand contact site, this peptide interferes with both activating receptor activator of NF-kappaB (RANK) and TNF-alphas recruitment and activation of osteoclasts. TNF-alpha antagonist has been used to block bone resorption in the study of systemic bone loss in rheumatoid arthritis and inflammatory bone destruction.

3 years

CC(C)C[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O)NC(=O)[C@@H](N)Cc1ccc(O)cc1

-20°C

12352202