TNF-alpha-IN-11

MedChem Express

TNF-alpha-IN-11 [2945197-77-1]

14

Research Use Only

C24H26N2O5

422.47

TNF-alpha-IN-11 (Compound 10) is a TNF-alpha inhibitor with a KD value of 12.06 microM. TNF-alpha-IN-11 binds to TNF-alpha and blocks the activation of TNF-alpha-trigged caspase and NF-kappaB signaling pathway. TNF-alpha-IN-11 inhibits the phosphorylation of IkappaBalpha, as well as the nuclear translocation of NF kappaB p65. TNF-alpha-IN-11 can be used for research of TNF-alpha-mediated autoimmune diseases[1].

O=C(N(CCC1=CC=C2C(OCO2)=C1)C(C3)=O)[C@H]3NC(C4=CC=C(C(C)(C)C)C=C4)=O

12131703