TNF-alpha-IN-11
HY-149331
Molecular Weight422.47
Product group Chemicals
Overview
- SupplierMedChem Express
- Product NameTNF-alpha-IN-11 [2945197-77-1]
- Delivery Days Customer14
- CertificationResearch Use Only
- Molecular FormulaC24H26N2O5
- Molecular Weight422.47
- Scientific DescriptionTNF-alpha-IN-11 (Compound 10) is a TNF-alpha inhibitor with a KD value of 12.06 microM. TNF-alpha-IN-11 binds to TNF-alpha and blocks the activation of TNF-alpha-trigged caspase and NF-kappaB signaling pathway. TNF-alpha-IN-11 inhibits the phosphorylation of IkappaBalpha, as well as the nuclear translocation of NF kappaB p65. TNF-alpha-IN-11 can be used for research of TNF-alpha-mediated autoimmune diseases[1].
- SMILESO=C(N(CCC1=CC=C2C(OCO2)=C1)C(C3)=O)[C@H]3NC(C4=CC=C(C(C)(C)C)C=C4)=O
- UNSPSC12131703