TNF-alpha/TNFSF2, Canine

MedChem Express

TNF-alpha/TNFSF2, Canine

10

Research Use Only

96.10

Tumor necrosis factor

Tumour Necrosis Factor alpha (TNF alpha) is a potent pro-inflammatory cytokine [1] . TNF alpha binds to its receptors, mainly TNFR1 and TNFR2, and then transmits molecular signals for biological functions such as inflammation and cell death [2] . TNF alpha stimulates NF-kappaB pathway via TNFR2 promotes cancer growth, invasion, and metastasis. Anti-TNF-alpha MAb significantly suppresses the tumor development in colitis-associated cancer (CAC) mouse [3] . TNF alpha as a proneurogenic factor activates the SAPK/JNK Pathway and can facilitate neuronal replacement and brain repair in response to brain injury [4] . TNF-alpha/TNFSF2 Protein, Canine is a recombinant protein produced in E. coli .

-20°C

12352202