TNKS2 Antibody

Cusabio

TNKS2 Antibody

20

ImmunoFluorescence, ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

Unconjugated

TNKS2

tankyrase 2

ARTD6, PARP-5b, PARP-5c, PARP5B, PARP5C, TANK2, TNKL, pART6, poly [ADP-ribose] polymerase tankyrase-2, ADP-ribosyltransferase diphtheria toxin-like 6, TNKS-2, TRF1-interacting ankyrin-related ADP-ribose polymerase 2, poly [ADP-ribose] polymerase 5B, protein poly-ADP-ribosyltransferase tankyrase-2, tankyrase II, tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2, tankyrase-like protein, tankyrase-related protein

Rabbit

IgG

Tankyrase-2

Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. Stimulates 26S proteasome activity.

Human

-20°C or -80°C

41116161