TNO155

AbMole BioScience

TNO155

9

1801765-04-7

Chemical

Research Use Only

C18H24ClN7OS

421.95

TNO155 is a first-in-class, selective, orally active wild-type SHP2 metamorphosis inhibitor with an IC50 value of 0.011 uM. tNO155 has good water solubility (0.736 mM), moderate lipophilicity (LogP=1.6), high lipophilic efficiency (>6), and no hERG inhibition (IC50 >30 uM) and no phototoxicity. Does not inhibit CYP450.

CC1OCC2(CCN(CC2)C3=CN=C(SC4=C(Cl)C(=NC=C4)N)C(=N3)N)C1N

12352200