Tolcapone [134308-13-7]

MedChem Express

Tolcapone [134308-13-7]

10

134308-13-7

Research Use Only

99.91

C14H11NO5

273.24

Tolcapone (Ro 40-7592) is a selective, orally active and powerful mixed (peripheral and central) COMT inhibitor with an IC50 of 773?nM in the liver[1]. Tolcapone is also a potent inhibitor of alpha-syn and Abeta42 oligomerization and fibrillogenesis[2]. Tolcapone induces oxidative stress leading to apoptosis and inhibition of tumor growth in neuroblastoma[3].

O=C(C1=CC(O)=C(O)C([N+]([O-])=O)=C1)C2=CC=C(C)C=C2

-20°C,2°C to 8°C

12352200