Tolcapone (Standard) [134308-13-7]
HY-17406R
Product group Assays
Overview
- SupplierMedChem Express
- Product NameTolcapone (Standard) [134308-13-7]
- Delivery Days Customer5
- CAS Number134308-13-7
- CertificationResearch Use Only
- Molecular FormulaC14H11NO5
- Molecular Weight273.24
- Scientific DescriptionTolcapone (Standard) is the analytical standard of Tolcapone. This product is intended for research and analytical applications. Tolcapone (Ro 40-7592) is a selective, orally active and powerful mixed (peripheral and central) COMT inhibitor with an IC50 of 773 nM in the liver[1]. Tolcapone is also a potent inhibitor of alpha-syn and Abeta42 oligomerization and fibrillogenesis[2]. Tolcapone induces oxidative stress leading to apoptosis and inhibition of tumor growth in neuroblastoma[3].
- SMILESO=C(C1=CC(O)=C(O)C([N+]([O-])=O)=C1)C2=CC=C(C)C=C2
- UNSPSC41116135