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ProductsBack/TOPBP1 Antibody

Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA846078ESR2HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA846078ESR2HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA846078ESR2HU at dilution of 1:100

TOPBP1 Antibody

CSB-PA846078ESR2HU

ApplicationsELISA, ImmunoHistoChemistry

Product group Antibodies

ReactivityHuman

TargetTOPBP1

Overview

Supplier
Cusabio
Product Name
TOPBP1 Antibody
Delivery Days Customer
20
Applications
ELISA, ImmunoHistoChemistry
Certification
Research Use Only
Clonality
Polyclonal
Conjugate
Unconjugated
Gene ID11073
Target name
TOPBP1
Target description
DNA topoisomerase II binding protein 1
Target synonyms
Dpb11, TOP2BP1, DNA topoisomerase 2-binding protein 1, DNA topoisomerase II-beta-binding protein 1, topoisomerase (DNA) II binding protein 1
Host
Rabbit
Isotype
IgG
Protein IDQ92547
Protein Name
DNA topoisomerase 2-binding protein 1
Scientific Description
Required for DNA replication. Plays a role in the rescue of stalled replication forks and checkpoint control. Binds double-stranded DNA breaks and nicks as well as single-stranded DNA. Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters. Down-regulates E2F1 activity and inhibits E2F1-dependent apoptosis during G1/S transition and after DNA damage. Induces a large increase in the kinase activity of ATR.
Reactivity
Human
Storage Instruction
-20°C or -80°C
UNSPSC
41116161

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