Top/HDAC-IN-1
HY-145851
Molecular Weight509.56
Product group Chemicals
Overview
- SupplierMedChem Express
- Product NameTop/HDAC-IN-1 [2775446-49-4]
- Delivery Days Customer10
- CertificationResearch Use Only
- Molecular FormulaC29H27N5O4
- Molecular Weight509.56
- Scientific DescriptionTop/HDAC-IN-1 (Compound 29b) is a topoisomerase/HDAC dual inhibitor with IC50s of 18, 230, 790, 87, and 5250 nM for HDAC1, HDAC2, HDAC3, HDAC6, and HDAC8, respectively. Top/HDAC-IN-1 exhibits potent antitumor activities against the HCT116 cell line with the IC50 of 180 nM. Top/HDAC-IN-1 efficiently induces apoptosis with G2 cell cycle arrest in HCT116 cells[1].
- SMILESCN1C2=C(C(N3CCC4=C(C13)NC5=C4C=C(C=C5)O)=O)C=C(C=C2)NCC6=CC=C(C=C6)/C=C/C(NO)=O
- UNSPSC12131703