Bio-Connect

Top/HDAC-IN-1

HY-145851
MedChem Express
Molecular Weight509.56
Product group Chemicals
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Overview

  • Supplier
    MedChem Express
  • Product Name
    Top/HDAC-IN-1 [2775446-49-4]
  • Delivery Days Customer
    10
  • Certification
    Research Use Only
  • Molecular Formula
    C29H27N5O4
  • Molecular Weight
    509.56
  • Scientific Description
    Top/HDAC-IN-1 (Compound 29b) is a topoisomerase/HDAC dual inhibitor with IC50s of 18, 230, 790, 87, and 5250 nM for HDAC1, HDAC2, HDAC3, HDAC6, and HDAC8, respectively. Top/HDAC-IN-1 exhibits potent antitumor activities against the HCT116 cell line with the IC50 of 180 nM. Top/HDAC-IN-1 efficiently induces apoptosis with G2 cell cycle arrest in HCT116 cells[1].
  • SMILES
    CN1C2=C(C(N3CCC4=C(C13)NC5=C4C=C(C=C5)O)=O)C=C(C=C2)NCC6=CC=C(C=C6)/C=C/C(NO)=O
  • UNSPSC
    12131703