Topo I/COX-2-IN-2

MedChem Express

Topo I/COX-2-IN-2 [2841455-91-0]

10

Research Use Only

C24H25ClN4O

420.93

Topo I/COX-2-IN-2 (Compound W10) is a potent dual-target inhibitor of Topo I and COX-2 with IC50 values of 0.90 microM and 2.31 microM, respectively. Topo I/COX-2-IN-2 induces cancer cell apoptosis through the mitochondrial pathway[1].

ClC1=C(C(NC2=CC=CC=C2C(NC3=CC=C(C=C3)N4CCNCC4)=O)=CC=C1)C

12131703