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Topo I/II-IN-2

HY-170912
MedChem Express
Molecular Weight418.48
Product group Chemicals
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Overview

  • Supplier
    MedChem Express
  • Product Name
    Topo I/II-IN-2
  • Delivery Days Customer
    5
  • Certification
    Research Use Only
  • Molecular Formula
    C25H26N2O4
  • Molecular Weight
    418.48
  • Scientific Description
    Topo I/II-IN-2 (Compound 3g) is an inhibitor of Topo I and Topo II. Topo I/II-IN-2 inhibits NCI-H446 cells and NCI-H1048 cells with IC50s of 1.30 microM and 1.42 microM, respectively. Topo I/II-IN-2 induces mitochondrial Apoptosis, mitochondrial dysfunction and activity generation. Topo I/II-IN-2 inhibits the PI3K/Akt/mTOR pathway. Topo I/II-IN-2 prevents SCLC (small cell lung cancer) cell proliferation, invasion, and migration in vitro. [1].
  • SMILES
    CC(C1)CC(C)CN1CC2=CC(OCO3)=C3C=C2C4=CC(C=CC5=C6OCO5)=C6C=N4
  • UNSPSC
    12352200

MSDS

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