Topoisomerase II inhibitor 11 [2476559-00-7]
HY-147861
Overview
- SupplierMedChem Express
- Product NameTopoisomerase II inhibitor 11 [2476559-00-7]
- Delivery Days Customer10
- CAS Number2476559-00-7
- CertificationResearch Use Only
- Molecular FormulaC27H21BrCl2N2O2S
- Molecular Weight588.34
- Scientific DescriptionTopoisomerase II inhibitor 11 (compound 3d) is a potent Topoisomerase II inhibitor, with an IC50 of 2.89 microM. Topoisomerase II inhibitor 11 shows 92.46% inhibition on renal cancer cell line A498 with an IC50 of 3.5 microM. Topoisomerase II inhibitor 11 causes cell cycle arrest at the G2/M phase leading to cell proliferation inhibition and pro-apoptotic activity[1].
- SMILESO=C(C1=C(C2=CC=CC=C2)N=C(SC=C3C4=CC=C(Cl)C=C4)N3C1C5=CC=C(Cl)C=C5)OCC.[H]Br
- UNSPSC12131703