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Topoisomerase II inhibitor 11 [2476559-00-7]

HY-147861
MedChem Express
CAS Number2476559-00-7
Product group Chemicals
Molecular Weight588.34
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Overview

  • Supplier
    MedChem Express
  • Product Name
    Topoisomerase II inhibitor 11 [2476559-00-7]
  • Delivery Days Customer
    10
  • CAS Number
    2476559-00-7
  • Certification
    Research Use Only
  • Molecular Formula
    C27H21BrCl2N2O2S
  • Molecular Weight
    588.34
  • Scientific Description
    Topoisomerase II inhibitor 11 (compound 3d) is a potent Topoisomerase II inhibitor, with an IC50 of 2.89 microM. Topoisomerase II inhibitor 11 shows 92.46% inhibition on renal cancer cell line A498 with an IC50 of 3.5 microM. Topoisomerase II inhibitor 11 causes cell cycle arrest at the G2/M phase leading to cell proliferation inhibition and pro-apoptotic activity[1].
  • SMILES
    O=C(C1=C(C2=CC=CC=C2)N=C(SC=C3C4=CC=C(Cl)C=C4)N3C1C5=CC=C(Cl)C=C5)OCC.[H]Br
  • UNSPSC
    12131703