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Topoisomerase IIalpha-IN-4

HY-151453
MedChem Express
Molecular Weight367.44
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Product group Chemicals
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Overview

  • Supplier
    MedChem Express
  • Product Name
    Topoisomerase IIalpha-IN-4 [2860554-26-1]
  • Delivery Days Customer
    10
  • Certification
    Research Use Only
  • Molecular Formula
    C25H21NO2
  • Molecular Weight
    367.44
  • Scientific Description
    Topoisomerase IIalpha-IN-4 (F2) is a non-intercalative ATP-competitive human DNA topoisomerase II inhibitor with an IC50 value of 3.8 and 10.1 microM for TopoIIalpha and TopoIIbeta, respectively. Topoisomerase IIalpha-IN-4 shows potent potency in apoptosis induction and cell cycle arrest in HepG2 cells. Topoisomerase IIalpha-IN-4 exhibits strong antitumor activities against human cancer cell lines, it can be used for the research of cancer[1].
  • SMILES
    O=C(NC1=CC=C(C2=CC=C3C=C(O)C=CC3=C2)C=C1)CCC4=CC=CC=C4
  • UNSPSC
    12131703